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Contact: info@afar.org 
Thursday, December 6, 2007 New York Academy of Sciences
Aging is characterized by genomic instability that may lead to cancer and alterations in body cell mass. Aging is also characterized by a metabolic decline exemplified by a decrease in the GH/IGF-1 axis and insulin resistance. This symposium will focus on these abnormalities and will try to link them in several ways. First, genetic modulation of genome maintenance leads to a premature aging phenotype and to a metabolic adaptation in the GH/IGF-1 axis. Second, longevity in model organisms has been linked to a dampening of the insulin/IGF-1 pathway, and this has now also been shown for human centenarians. Third, sirtuins have a role as a genetic switch between normal metabolism and enhanced genome protection. Lastly the novel mitochondrial peptide humanin has appeared as a potential key player in the general response to stress through its anti-apoptotic and metabolic actions. This one-day conference will focus on the intersection between aging, genome maintenance and metabolism. Organizing Committee Yousin Suh, PhD Nir Barzilai, MD Jan Vijg, PhD _____________________________________________ Program:7:30 - 8:20 Registration 8:20 - 8:30 Welcome Address Yousin Suh, PhD (Albert Einstein College of Medicine, Bronx) 8:30 - 9:15 Keynote Lecture Introduction by Nir Barzilai, MD (Albert Einstein College of Medicine, Bronx) Pinchas H. Cohen, MD (University of California, Los Angeles) IGF, Aging and Cancer
Morning Session
9:15 - 9:45 Jan Hoeijmakers, PhD (Erasmus University, Rotterdam, The Netherlands) Life-span studies in DNA repair deficient mice 10:15 - 10:45 Coffee Break 10:45 - 11:15 Judy Campisi, PhD (Lawrence Berkeley National Laboratory, Berkeley) Senescence, growth factors, and cancer 11:15 - 11:45 Nir Barzilai, MD (Albert Einstein College of Medicine, Bronx) Telomere length in centenarians and insulin action 11:45 - 12:15 Yousin Suh, PhD (Albert Einstein College of Medicine, Bronx) IGF-1, genome maintenance and exceptional longevity 12:15 - 1:45 Lunch and Glenn Foundation Lecture Introduction by Nir Barzilai, MD (Albert Einstein College of Medicine, Bronx) David Sinclair, PhD (Harvard Medical School, Boston) Role of SIRT1 in maintaining the epigenome
Howard Pack Foundation Session
1:45 - 2:15 Radhika Muzumdar, MD (Albert Einstein College of Medicine, Bronx) Metabolic intervention in premature aging 3:15 - 3:45 Coffee Break 3:45 - 4:15 Colette Knight, MD (Albert Einstein College of Medicine, Bronx) Central metabolic effects of Sirtuins 4:15 - 4:45 Leonard Guarente, PhD (Massachusetts Institute of Technology, Cambridge) Sirtuins in aging and metabolism 4:45 - 5:00 Summary and Closing Remarks Nir Barzilai, MD (Albert Einstein College of Medicine, Bronx) Jan Vijg, PhD (Buck Institute for Age Research, Novato)
_____________________________________________ Sponsors to Date: Albert Einstein College of Medicine-Institute for Aging Research and Cancer CenterAmerican Federation for Aging Research Glenn Foundation for Medical Research The Pack Family Foundation NIH PO1 AG027734, NIH PO1021654, NIH PO1 AG017242 | ||||
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American Federation for Aging Research (AFAR) | 55 West 39th Street, 16th Floor | New York, NY 10018 Phone: (212) 703-9977 | Toll-free: (888) 582-2327 | Fax: (212) 997-0330 E-mail: grants@afar.org or info@afar.org |
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